Iris Morton, DDS, MS, and Ronald S. Brown, DDS, MS, discuss vitamin B12 patient care and the pathophysiology related to the oral manifestations of vitamin B12 serum values. Issues of particular importance to clinical dentistry are addressed. This article is peer-reviewed and available for 2 hours of CE credit. Learning Objectives: After participating in this CE activity, the individual will learn: Dental concerns related to vitamin B12. The pathophysiology related to oral manifestations of vitamin B12 serum values.